Masa Tsuchiya announces in-depth study on genomic mechanism for cell-fate change in the field of bioscience

Ad blocking detected

Thank you for visiting CanadianInsider.com. We have detected you cannot see ads being served on our site due to blocking. Unfortunately, due to the high cost of data, we cannot serve the requested page without the accompanied ads.

If you have installed ad-blocking software, please disable it (sometimes a complete uninstall is necessary). Private browsing Firefox users should be able to disable tracking protection while visiting our website. Visit Mozilla support for more information. If you do not believe you have any ad-blocking software on your browser, you may want to try another browser, computer or internet service provider. Alternatively, you may consider the following if you want an ad-free experience.

Canadian Insider Ultra Club
$500/ year*
Daily Morning INK newsletter
+3 months archive
Canadian Market INK weekly newsletter
+3 months archive
30 publication downloads per month from the PDF store
Top 20 Gold, Top 30 Energy, Top 40 Stock downloads from the PDF store
All benefits of basic registration
No 3rd party display ads
JOIN THE CLUB

* Price is subject to applicable taxes.

Paid subscriptions and memberships are auto-renewing unless cancelled (easily done via the Account Settings Membership Status page after logging in). Once cancelled, a subscription or membership will terminate at the end of the current term.

Masa Tsuchiya announces in-depth study on genomic mechanism for cell-fate change in the field of bioscience

The new research work titled, "Underlying Genomic Mechanism for Cell-Fate Change from Embryo to Cancer Development" is written by Masa Tsuchiya and the team

PR Newswire

NEW YORK, May 24, 2019 /PRNewswire/ -- In the research paper, they have conducted an extensive study on the general genomic mechanism that underlines the cell-fate change from embryo to cancer development.

Masa and the team have demonstrated the existence of self-organized critical control (SOC) of whole gene expression at both the cell population and single-cell level. The team of researchers have addressed two fundamental questions viz., whether there is an underlying principle that self-regulated whole-genome expression and if a universal mechanism exists to guide the self-organization so as to determine the change in cell fate?

The team has further stressed the existence of a critical point (CP), which plays an essential role in determining distinct response domains (critical states). It was observed that the CP (critical gene set) was analogous to the centre of mass (CM) of genome expression and revealed fixed point behaviour according to temporal expression variance. Furthermore, the findings showed that the activation of the CP was essential for the occurrence of cell-fate change; conversely, inactivation of the CP did not undergo cell-fate change.

Going by the classical concept of self-organized critical control, Masa and the team noticed that the activation and inactivation of CP suggested that there might be another layer of a macro-state (genome state) composed of distinct micro-critical states, which was discovered by them. The findings on the CP allowed the team to systematically determine critical states for both cell population and single cell regulation.

However, Masa and the team have suggested further studies to clarify the underlying molecular mechanism. According to them, "the development of a theoretical foundation for the autonomous critical control mechanism in genome expression as revealed" in their findings "is expected to open new doors for a general control mechanism of the cell-fate change and genome computing".

Furthermore, Masa and the team have expressed that the strong interaction among genes with extremely different expression variance and physiological roots push for a complete re-shaping of the present molecular – reductionist view of biological regulation.

They have concluded affirming that the view of the genome acting as an integrated dynamical system is here to stay. The research conducted by the team is a valuable contribution to the field of bioscience. Their work will act as a catalyst and will promote further research. Masa is the founder of SEIKO Life Science Laboratory, which is committed to the goal to support the development of breakthrough biomedical technologies. Masa Tsuchiya is also a leading scientist and his research will certainly add merit to the war against cancer.

Read more about: Underlying Genomic Mechanism for Cell-Fate Change from Embryo to Cancer Development

Press Contact:

Tiffany Keller
+441442781196
[email protected]

 

Cision View original content to download multimedia:http://www.prnewswire.com/news-releases/masa-tsuchiya-announces-in-depth-study-on-genomic-mechanism-for-cell-fate-change-in-the-field-of-bioscience-300856668.html

SOURCE Masa Tsuchiya

Copyright CNW Group 2019

Comment On!

140
Upload limit is up to 1mb only
To post messages to your Socail Media account, you must first give authorization from the websites. Select the platform you wish to connect your account to CanadianInsider.com (via Easy Blurb).