Aarvik Therapeutics Announces Validation of Novel Tetravalent Antibody Platform

Ad blocking detected

Thank you for visiting CanadianInsider.com. We have detected you cannot see ads being served on our site due to blocking. Unfortunately, due to the high cost of data, we cannot serve the requested page without the accompanied ads.

If you have installed ad-blocking software, please disable it (sometimes a complete uninstall is necessary). Private browsing Firefox users should be able to disable tracking protection while visiting our website. Visit Mozilla support for more information. If you do not believe you have any ad-blocking software on your browser, you may want to try another browser, computer or internet service provider. Alternatively, you may consider the following if you want an ad-free experience.

Canadian Insider Ultra Club
$500/ year*
Daily Morning INK newsletter
+3 months archive
Canadian Market INK weekly newsletter
+3 months archive
30 publication downloads per month from the PDF store
Top 20 Gold, Top 30 Energy, Top 40 Stock downloads from the PDF store
All benefits of basic registration
No 3rd party display ads
JOIN THE CLUB

* Price is subject to applicable taxes.

Paid subscriptions and memberships are auto-renewing unless cancelled (easily done via the Account Settings Membership Status page after logging in). Once cancelled, a subscription or membership will terminate at the end of the current term.

Aug 19, 2022 09:01 am
HAYWARD, Calif. -- 

Aarvik Therapeutics announced the recent publication by Sachdev Sidhu, Ph.D., Co-founder of Aarvik Therapeutics, and his colleagues of a study validating the novel tetravalent antibody platform that forms a core component of innovation at Aarvik. This study by Miersch et al. uses modular design principles to combine neutralizing antibodies against two independent epitopes of the SARS-COV-2 spike protein into a single bi-paratopic, tetravalent antibody. The tetravalent antibody behaves like conventional IgGs on yield, purity, stability, and solubility but demonstrates potency and breadth of coverage that far exceed conventional bivalent IgGs. This tetravalent antibody platform offers enormous potential not just in infectious disease but also in oncology and other therapeutic areas.

The proprietary tetravalent antibody platform enables the efficient creation of antibodies in a high-throughput manner. Aarvik utilizes this platform to rapidly design and generate tetravalent antibodies against a variety of oncology targets. These antibodies can elegantly combine multiple independent antibody paratopes to potentially improve the clinical activity of various therapeutic modalities, including antibody drug conjugates (ADCs), which currently use conventional IgG antibodies.

“We are extremely excited to see the expanding proof of concept for this powerful tetravalent antibody platform,” said Jagath Reddy Junutula, Ph.D., Co-founder, President, and CEO of Aarvik Therapeutics. “Dr. Sidhu is a world-renowned leader in protein engineering, and Aarvik substantially benefits from the deep expertise possessed by him and his team in engineering novel antibodies.”

The study’s principal investigator, Sachdev Sidhu, Ph.D., added, “We are excited to work with the Aarvik team and to continue exploration of this modular platform and its potential to generate functional antibodies with previously unrealized biological and therapeutic properties.”

About Aarvik Therapeutics

Aarvik Therapeutics combines a unique, proprietary modular platform with multiple target mechanisms and therapeutic modalities to develop novel molecules with an improved therapeutic index for oncology and other diseases. Backed by extensive scientific, research, drug development and business expertise from its founders, team members, SAB and Board, Aarvik Therapeutics is applying its vision and passion to create transformational benefit for patients with cancer and other diseases.

For additional information, visit www.aarviktx.com.

Pradeep Fernandes
[email protected]

Comment On!

140
Upload limit is up to 1mb only
To post messages to your Socail Media account, you must first give authorization from the websites. Select the platform you wish to connect your account to CanadianInsider.com (via Easy Blurb).